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Pudendal Neuralgia

Pudendal NeuralgiaThe pudendal nerve is the main nerve of the perineum. The perineum is the area between the testicles and anus of a man, and the vagina and anus of a woman. When this nerve suffers an injury, it can result in the most chronic and disabling form of pelvic pain, pudendal neuralgia.[1]

Although pudendal neuralgia has come to be used interchangeably with pudendal nerve entrapment and Alcock Canal Syndrome, a 2009 study found pudendal neuralgia to be a “rare event” and “no evidence to support equating the presence of this syndrome with a diagnosis of pudendal nerve entrapment”. This means one might display all the symptoms of pudendal neuralgia but not actually have an entrapped (pinched) pundendal nerve. [7] Entrapment is just one possible cause.

Infrequency, however, does not change the fact that pudendal neuralgia is a debilitating and extremely unpleasant condition. The agony can become so intense, individuals are unable to urinate, have intercourse, or even sit without experiencing intense, shooting, burning pain in the genitals and seat region.

Pudendal neuralgia is an uncommon and complex diagnosis distinct from other forms of chronic pelvic pain. Fortunately, the physicians at the Ainsworth Institute of Pain Management are uniquely trained and specialize in the treatment of pelvic pain, including PN. Our board certified pain management specialists can offer you a combination of treatment options for PN that are not available anywhere else.

What is Pudendal Neuralgia?

Pudendal Neuralgia MaleAs mentioned above the pudendal nerve is the main nerve running through the perineum, carrying sensation from the external genitals of both sexes to the anus. It is also connected to various pelvic muscles including the urethral sphincter and the external anal sphincter. The symptoms of pudendal neuralgia occur as a result of some kind of injury to the pudendal nerve.

Entrapment is one possibility that has been of increasing interest to physicians as it suggests a surgical or treatable solution. This is when the tissue that surrounds the pudendal nerve becomes inflamed and pinches it. Entrapment typically occurs in one of 3 regions:

 Between the sacrotuberous and sacrospinous ligaments (interligamentous plane)
 Alcock canal
 As the nerve passes through a tight osteofibrotic canal at the entrance to the base of the penis.[11]

Pudendal Neuralgia is more common in women than men (7:3). In fact it is often called “obstetric neuropathy” because of it’s prevalence during childbirth. The average age of PN’s onset is 50-70.

The Anatomy of Pudendal Neuralgia

The Pudendal nerve is derived from anterior divisions of the ventral rami of the S2, S3 and S4 nerves of the sacral plexus. It accompanies the internal pudendal Pudendal Neuralgia Pelvic Innervationartery along the lateral wall of the ischiorectal fossa in the pudendal canal. The pudendal nerve carries sensory, motor, somatic and sympathetic innervation[8] and innervates the external genitalia of both men and women (including bulbospongiosus and ischiocavernosus), as well as the bladder and rectum.

It is considered the MAIN nerve of the perineum and chief sensory nerve of the external genitalia as it supplies the skin and muscles of the perineum, the external urethral sphincter and external anal sphincter. The pudendal nerve contains sympathetic fibers that innervate penile erectile tissue making its function crucial for intercourse.

Its course through the pelvic is complex and tortuous, yet predictable. The pudendal nerve originates in Onuf’s nucleus in the sacral region of the spinal cord, coursing through the pelvic region then exiting the pelvis through the greater sciatic notch between the piriformis and coccygeus muscles. It curves around the ischial spine and sacrospinous ligament and enters the perineum through the lesser sciatic foramen.[9] Its branches include the inferior rectal nerves, perineal nerve, and it terminates as the posterior scrotal/labial nerves and dorsal nerve of the penis/clitoris.

What are the Symptoms?

 Pain in penis, scrotum, labia, perineum or anorectal region[2]
 Mild to severe burning and/or lancinating pain
 Pain worsens when sitting down[3],[4]
 Bowel and/or bladder incontinence
 Painful ejaculation
 Cutaneous hyperalgesia, deep tenderness, paresthesia, tingling, and/or numbness

The pain associated with pudendal neuralgia is typically unilateral and rarely affects both sides. (Bilateral pudendal neuralgia is most likely the result of repetitive trauma, like riding a bicycle or a horse.)

What are the Causes?

Pudendal neuralgia can be caused by any one of a diverse group of mechanisms.

 Childbirth – most common causePudendal Neuralgia Examination
 Entrapment – Pinched nerve
 Trauma – fracture of the ischial spine, penetration with a large dull needle, surgery (direct injury to pudendal nerve or residual scar in the vicinity)
 Symptomatology after pelvic surgery (Abdominoperineal Resection) with extensive dissection and post-op urinary incontinence[10]
 Acute traumatic vulvovaginal hematoma
 Pelvic Sling Operations (if symptoms persist beyond 6 weeks the sling should be removed)
 Transvaginal mesh surgery (more likely to affect the Obturator Nerve)
 Cancer (compression from tumor)
 Prolonged straining and difficulty passing stools

What are my Treatment Options?

Your pain management physician will diagnose pudendal neuralgia according to the criteria established at Nantes in 2006. These include:

  1. Pain in the anatomical territory of the pudendal nerve
  2. Pain is worsened by sitting
  3. The patient is not woken at night by the pain
  4. No objective sensory loss on clinical examination
  5. Positive anesthetic pudendal nerve block

Pudendal Neuralgia Physical ExamExclusion criteria are purely coccygeal, gluteal, or hypogastric pain, exclusively paroxysmal pain, exclusive pruritus, and presence of imaging abnormalities able to explain the symptoms.

The doctor will need to ascertain your complete medical history, conduct a comprehensive physical examination, and administer a diagnostic pudendal nerve block in order to determine if you satisfy these criteria for pudendal neuralgia. The pudendal nerve block is typically performed under ultrasound guidance as the nerve passes between the sacrospinous and sacrotuberous ligaments,[9] although it can also be accomplished with the aid of fluoroscopy with the target being the ischial spine. A response to the block is considered “positive” when you experience a temporary decrease, or even elimination, of pain.

Interventional Pain Management Treatments

Pudendal Nerve Block – This injection is considered to be the gold-standard, first line treatment not only for managing the symptoms of pudendal neuralgia, but for establishing a diagnosis of pudendal neuralgia in the first place. Typically performed under ultrasound guidance, your physician will insert a small needle along the course of the pudendal nerve and inject a small amount of local anesthetic (sometimes with the addition of cortisone). In the case of true pudendal neuralgia, pain relief will be immediate and dramatic.

Trigger Point Injections – This procedure involves using a thin needle to break up small contractures in local muscles called trigger points. These trigger points can cause pain in the pelvic region and contract around the pudendal nerve, essentially strangling it, causing the nerve to become painful. This modality is rarely as effective as a nerve block.

Botox Injections – This premise is the same as trigger point injections in that the goal is to relax the local musculature in the pelvic region by using Botulinum Toxin (Botox) to safely paralyze the implicated muscles in the area.

Superior Hypogastric Block – This procedure can be used to treat pain in the pelvic and perineal region from a variety of causes simultaneously. A thin needle is inserted with the assistance of fluoroscopy through the skin and advanced toward the L5 vertebra at the location of the superior hypogastric plexus. A blockade here has been reported to decrease pelvic pain by 70%.[12]

Ganglion of Impar Block – The premise of this procedure is the same as the superior hypogastroc block, however the target here is the ganglion of impar – another structure located in the pelvic region also implicated in moderating pelvic pain. This procedure is also performed under fluoroscopic guidance with the target being a small area directly in front of the coccyx (tailbone). This modality is extremely effective in treating pelvic pain and studies have reported 70-100% pain relief from this procedure.[13]

Neurolysis & Ablation – In cases where an injection provides only temporary relief, neurolysis or neuroablation can be utilized to increase the duration. There are several different methods that can be used:

  • Radiofrequency Ablation (RFA) – Radio waves are applied to a nerve or plexus, preventing the transmission of pain.
  • Cryoablation – Similar to RFA, however cold temperatures are applied to the area instead of radio waves.
  • Chemodenervation – The premise is the same as cryoablation and RFA in that the goal is to prevent a nerve or plexus from transmitting pain; rather than applying mechanical stress to the nerve through radiowaves or cold temperatures, small amounts of either alcohol or phenol are injected to block the nerve’s ability to transmit a signal.

IV Infusion Therapy – An increasingly popular procedure for treating a variety pain syndromes, as well as depression and anxiety. Patients are hooked up to an IV and special medications are administered intravenously. The infusions can take as little as 30 minutes to complete.

Spinal Cord Stimulation (SCS) – This is a commonly performed procedure for a variety of pain syndromes. SCS utilizes technology similar to that of cardiac pacemakers whereby small electrodes are placed into the epidural space near the spinal cord. These electrodes will produce a small electrical current over the spinal cord that interfere with pain signals. In the case of pelvic pain, the leads are placed over the sacral nerve roots or in the thoracic region.[13] In recalcitrant cases of pudendal neuralgia, a paddle lead can be placed over the conus.[14]  Our doctors at the Ainsworth Institute have pioneered a unique lead placement combination that isolates the pain of the pudendal nerve and are reported amazing successes.

Dorsal Root Ganglion (DRG) Stimulation  This amazing therapy only became commercially available in the United States in 2016, however it was already available in Australia and Europe for 8-9 years before that.  Dr. Hunter performed one of the very first in the country and has been chosen to teach this procedure to others due to his high level of expertise.  Since that time, we have treated a number of patients with pudendal neuralgia and the results have been astounding!  The DRG acts like a filter in normal nervous systems, however conditions like Pudendal Neuralgia cause that filter to turn off, letting excessive sensation to get into the spinal cord – that sensation becomes painful.  That is why normal activities like sitting feel painful.  In DRG Stimulation, a small electrode is placed over the DRG that sends an electrical signal to turn the filter back on.  The results are almost instantaneous.  See if you are a candidate.

Peripheral Nerve Stimulation – The premise is similar to SCS but rather the leads are placed on the affected nerve – in the case of PN, the lead is placed on the pudendal nerve.[15]

Intrathecal Pumps – A small catheter is placed in the subarachnoid space (just below the epidural space) and extremely small amounts of medication are slowly delivered directly over the spinal cord. This enables your physician to provide the same medications you might take orally to manage the pain but at a fraction of the dose – thus decreasing the side effects.  More importantly, our doctors have been putting a revolutionary drug inside the pumps called ziconotide and are reported amazing successes!

Other Treatment Options

Medication Management & Pharmacologic Therapy: Medications are typically the first treatment modalities tried, but rarely the most effective – NSAIDs, Opioids (some preference of kappa agonists in females[16]), Antidepressants, Anticonvulsants, Muscle relaxants (tizanidine or baclofen).

Physical Therapy & Conservative Measures: Also rarely effective when used alone. Includes perianal TENS, relaxation exercises, biofeedback, massage therapy, pelvic floor exercises, and acupuncture.

The Ainsworth Institute is Here to Help

The doctors at the Ainsworth Institute of Pain Management specialize in managing and treating Pudendal Neuralgia. Dramatic improvements in pain and quality of life are a single phone call away. Schedule an appointment today with one of our board certified pain management experts to discuss what options for treatment may best suit your needs.

References

[1] Labat JJ, Robert R, Delavierre D, et al. Symptomatic approach to chronic neuropathic somatic pelvic and perineal pain. Prog Urol. 2010;20(12):973-981

[2] Robert R, Prat-Pradal D, Labat JJ, et al. Anatomical basis of chronic perineal pain: role of the pudendal nerve. Surg Radiol Anat. 1998;20:93-98.

[3] Benson JT, Griffis K. Pudendal neuralgia, severe pain syndrome. Am J Obstet Gynecol. 2005;192(5):1663-1668.

[4] Carmel M, Lebel M, Tu le M, Pudendal nerve neuromodulation with neurophysiology guidance: a potential treatment option for refractory chronic pelvic-perineal pain. Int Urogynecol J. 2010; 21:613-616.

[5] Stav, K, Dwyer, PL, Roberts, L. Pudendal neuralgia. Fact or fiction?”. Obstet Gynecol Surv 64 (3): 190–9.

[6] Bonica JJ: The Management of Pain. Philadelphia, Lea & Febiger, 1953.

[7] Orphanet. Pudendal neuralgia. Available at http://orpha.net.   Accessed October 30, 2011

[8] Grant’s atlas of anatomy 11th edition. pg 221

[9] Clinically Oriented Anatomy 4th edition

[10] Gomella LG: The 5-Minute Urology Consult. Philadelphia, Lippincott Williams & Wilkins, 2010.

[11] Bellingham G, Bhatia A, Chan C, et al. Randomized Controlled Trial Comparing Pudendal Nerve Block Under Ulrasound and Fluoroscopic Guidance. Regional Anesthesia and Pain Medicine. 2012;37(3):262-266.

[12] De Leon Casasola OA, Kent E, Lema MJ: Neurolytic superior hypogastric plexus block for chronic pelvic pain associated with cancer. Pain. 1993; 54:145-151.

[13] Hunter C, Davé N, Diwan S, Deer T. Neuromodulation of Pelvic Visceral Pain: A Review of the Literature and Case Series of Potential Novel Targets for Treatment. Pain Practice 2013;13(1):3-17.

[14] Rigoard P, Delmotte A, Moles A, et al. Successful Treatment of Pudental Neuralgia with Tricolumn spinal cord stimulation: Case report. Neurosurgery. 2012;71(3):E757-E762.

[15] Bennet RC, et al. Nonsacral neuromodulation. In: Goldman HB, Vasavada SP, eds. Female Urology: A Practical Clinical Guide. Totowa, NJ: Humana Press, 2007.

[16] Chia Y, Chow L, Hung C, et al. Gender and pain upon movement are associated with the requirements for post-operative patient-controlled iv analgesia: a prospective survey of 2,298 Chinese patient. Con J Anaesth 2002;49:249-255.

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